Chronic recurrent aphthous stomatitis (stomatitis chronica aphtosa recidiva) is a chronic inflammatory disease of the oral mucosa of an infectious-allergic nature, characterized by periodic remissions and frequent exacerbations. Morphological elements on the oral mucosa are the so-called "ulcerative formations", that is, apht characterized by periodic remissions and partial exacerbations with a rash of aphtha. According to the latest publications of domestic and foreign authors, HRAS is usually considered as a polyetiological disease that plays a role in the formation and the nature of the course of the pathological process. The factor causing chronic aphthous stomatitis is staphylococcal infection, adenovirus, allergies, immune disorders, as well as diseases of organs and systems. First of all, it is a local effect aimed at reducing pain that makes it difficult to eat up to forced starvation, as well as at the speedy regeneration of the defect. Secondly, it is the regulation of the body's immunocompetent systems and a decrease in the level of bacterial allergies. In addition, the identification and treatment of background diseases with the involvement of specialists of different profiles (Lukinykh L.M., 2004; Savkina G.D., 2005; Drobotko JI.H., 2008).
Introduction. A correct diagnostic of recurrent aphthous stomatitis (RAS, sometimes also called recurrent oral ulcers or ulcers) is a central element of dentistry issues. Aphthous ulcers have been carefully defined so that they can be differentiated from many other types of recurrent oral ulcers that are not associated with systemic abnormalities (M.Kh. Ibragimova, 2019). Objectively, the prevalence rate is incredibly high, but if RAS is defined as more than two spontaneously occurring episodes per year, then the average prevalence in the population is about 10%, which seems reasonable. Many studies struggle with definitions and ask if subjects ever had mouth ulcers. Reported estimates range from 1.5 to 28% in different parts of the world according to the WHO, suggesting that there may be genetic differences that account for these geographic differences. Current evidence suggests that RAS may be the result of an abnormal cascade of cytokines in the oral mucosa, which leads to a cell-mediated immune response directed to the focal area of the oral mucosa (Alimova D.M., 2021).
Currently, one of the most frequent diseases in children is a herpetic infection, which is explained not only by the prevalence of herpes simplex virus (HSV), but also by the peculiarities of the development of the immune system in a developing child's body. Questions of the general status of herpetic stomatitis in children is important. The purpose of the study was to study the immunological parameters of the oral cavity in children with acute herpetic stomatitis in the dynamics before and after treatment with Kyzyl May. In 62 children with acute herpetic stomatitis who applied to the department of pediatric therapeutic dentistry at TSDI, clinical and immunological studies were conducted. Based on the obtained clinical and immunological data, the high efficacy of Kyzyl May is effective in the treatment of acute herpetic stomatitis.
Среди стоматологических заболеваний патология слизистой оболочки полости рта занимает особое место, так как ее возникновение и клинические проявления часто связаны с влиянием многочисленных местных и общих факторов. Отличительными особенностями я афтозного стоматита у женщин фертильного возраста, принимающих метотрексат, были наличие выраженного болевого симптома, вялотекущее медленно прогрессирующее перманентное течение, длительный период восстановительных процессов, увеличение и болезненность регионарных лимфатических узлов.
According to the results of an epidemiological dental survey of the population, the proportion of diseases of oral mucosa in adults aged 35-44 years is 8.6%, among them recurrent aphthous stomatitis is in first place with an indicator of 3.67%.
Chronic recurrent aphthous stomatitis (CRAS) is a chronic inflammatory disease of the oral mucosa and characterized by the appearance of aphthous ulcers with a long course and periodic remissions and exacerbations.